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KMID : 0606719940010020066
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Bulletin of Yong-In Psychiatric Institute
1994 Volume.1 No. 2 p.66 ~ p.74
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The Effect o Glycine as an Adjuvant to Haloperidol in Schizophrenia
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윤충한/Yoon, Choong-Han
최소현/곽상곤/배석주/강윤형/Choi, So-Hyun/Kwak, Sang-Gon/Bae, Suk-Ju/Kang, Yun-Hyung
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Abstract
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Object) We studied the effect of glycine as an adjuvant to haloperidol in schizophrenic patients and tested the glutamatergic hypothesis of schizophrenia arisen from the phencyclidine model of psychosis.
Method) The subjects were 38 male schizophrenic inpatients (DSM-III-R) in the Yong-In mental hospital. After washout period of drugs for 10 days, they were randomly devided into experimental group and control group. Experimental group received 10mg of haloperidol with 15g of glycine per day for 6 weeks and control group received 10mg of haloperidol with 15g of placebo per day for 6 weeks. And the positive and negative syndrome scale(PANSS) was performed at baseline and 2nd week, 4th week and 6th week there-after.
Results) There were significant improvement in PANSS total scores, PANSS total positive scale scores, PANSS total negative scale scores, PANSS total general psychopathology scale scores and many items of PANSS. No differences in the scores of items of PANSS which showed improvement were found in experimental group compared to control group.
Conclusion) Glycine had no adjunctive effect to haloperidol for the treatment of schizophrenia and this result did not support the glutamatergic hypothesis of schizophrenia.
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